I'm looking for an affiliate add-on that has support for 2 tier payouts.
Whereby affiliates make a percentage of each sale made by the other affiliates that they have referred.
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There are just a few affiliate add-ons for ExpressionEngine. I don't think any of them supports what you're asking, but maybe it's better to talk to respective developers.
You can consider building something on top of existing add-on, or integrate some non-EE solution (both would require custom coding).